Uniform distribution of endovascular coils may help in the treatment of cerebral aneurysms, study shows


A new study highlights that a more uniform distribution of endovascular coils may help in the treatment of cerebral aneurysms. The study titled “The impact of coil shape design on angiographic occlusion, packing density and coil mass uniformity in aneurysm embolization: an in vitro study” was published in the June edition of the Journal of NeuroInterventional Surgery.

Researchers found that the novel triangular primary wind design of Deltapaq endovascular microcoils (Codman Neurovascular) achieved a tighter packing density and a more uniform distribution of the coil mass across the aneurysm dome in comparison with helical and complex endovascular microcoils.  Deltapaq coils were also more likely to have the highest rate of angiographic occlusion. 


Researchers concluded that the evaluation of emerging coil technologies with respect to treatment durability may be well served by an assessment of their uniformity of distribution within an aneurysm, in addition to the traditional packing density and angiographic occlusion scoring methods.   

“This study suggests that the uniformity across the dome of the aneurysm may play an important role in enhancing the durability of endovascular treatment and is an important area for further study and confirmation,” said Bernard R Bendok, study co-author and associate professor of Neurological Surgery and Radiology at Northwestern University’s Feinberg School of Medicine, Chicago, USA. “The application of a coil uniformity model may provide valuable design information.”   


In the in vitro study, Deltapaq coils were more uniformly distributed in the dome of the aneurysm than were the complex Cashmere (Codman Neurovascular) and helical Helipaq coils (Codman Neurovascular). The average packing density for Deltapaq (39.1 %) was significantly higher than the complex (35.2%) and helical (32.2 %) coil systems.  In addition, Deltapaq had the highest rate of angiographic occlusion (Class 1) based on the Raymond score, a qualitative measure of permeability. 


“This study encourages clinicians and industry to look at the coil uniformity index, in addition to packing density and occlusion rates, when deciding which endovascular coil to use,” said Karen Prange, general manager and vice president, Codman Neurovascular. “We are pleased to see that the Deltawind technology performed favorably in this assessment model.”


The study was funded by a research grant from Micrus Endovascular, which now operates under Codman Neurovascular. 


In addition to Bendok, study authors include:  Manik Mehra, Matthew J Gounis, and Robert M King, from the New England Center for Stroke Research, University of Massachusetts Medical School; Ali Shaibani, Michael C Hurley and Guilherme Dabus, from Northwestern University’s Feinberg School of Medicine; Elad I Levy, School of Medicine and Biomedical Sciences, University of New York, Buffalo; and Fatimaezzahra E Labdag, from Micrus Endovascular.