Research shows brain rhythm changes occur ‘within minutes’ of DBS surgery for depression


New research published in Translational Psychiatry presents evidence that brief intraoperative exposure to therapeutic deep brain stimulation (DBS) at the time of implantation surgery induces rapid and consistent electrophysiological brain state changes within minutes—shedding light on the mechanism of action by which DBS is able to ease depressive symptoms and, potentially, paving the way for this therapeutic approach to treatment-resistant depression to be enhanced in the future.

These intraoperative brain state changes—which were indexed by a decrease in beta power, measured at the site of stimulation, in a study—are seen in individual subjects and are correlated with a significant and sustained decrease in depressive symptoms outside of the operating room without additional stimulation. As such, this research may help to establish reduction in beta power as a novel biomarker for DBS treatment optimisation, according to a Mount Sinai press release.

The data presented come from a collaborative study at Emory University in Atlanta, USA and the Icahn School of Medicine at Mount Sinai in New York City, USA. Led by Helen S Mayberg, Mount Sinai Professor in Neurotherapeutics and founding director of the Nash Family Center for Advanced Circuit Therapeutics at Mount Sinai (New York City, USA), the research is part of an ongoing National Institutes of Health (NIH) BRAIN Initiative-funded grant.

While still an experimental treatment, DBS of the subcallosal cingulate (SCC; Area 25)—a brain area that has been implicated as playing a major role in depression—has been repeatedly demonstrated as a promising intervention for patients suffering from treatment-resistant depression. Acute behavioural changes and long-term antidepressant response can be reliably elicited with stimulation of this well-defined, surgically targeted depression circuit, using individualised neuroimaging guidance.

However, the exact means by which DBS achieves this is not known for certain, and this has led scientists worldwide to search for objective biomarkers linked to DBS treatment efficacy in order to further optimise this experimental approach, and ultimately gain regulatory approval and disseminate it to those in need. And, while the clinical effectiveness of DBS over the course of six months of treatment has been repeatedly demonstrated, there are differences in the timeline of recovery across different patients. Understanding the mechanisms of these initial rapid and reproducible behavioural effects, and their role in predicting the more critical long-term response trajectories, will be key to effective treatment and future study design.

Allison C Waters (Credit: Mount Sinai Health System)

“What we found was that within minutes of stimulation inside the operating room, there was a change in the beta brain rhythm,” said Allison C Waters, assistant professor of psychiatry and neuroscience at Icahn Mount Sinai, and co-first author of the recent Translational Psychiatry paper. “Patients who showed larger changes then experienced greater relief from their depression in the week after surgery.

“The beta rhythm is conventionally associated with the brain’s determination of whether to stop or keep going with a course of action, which is why neurologists target beta with DBS to treat disorders of movement. We have not had a clear signal to target with DBS for depression, but now we can speculate as to how the beta signal might function in this context: a release of the brake that generates fatigue and slowness, or interrupting a habitual cycle of negative, self-focused thought.”

“We were able to leverage machine learning and explainable artificial intelligence approaches to explore unknown (hidden) changes in brain state that would explain the obvious behavioural changes previously observed,” added Mohammad Sendi, PhD candidate in the Biomedical Engineering Department of Emory University and Georgia Institute of Technology (Atlanta, USA), and co-first author of the paper.

In the collaborative study, eight treatment-resistant depression patients underwent electrophysiological recording in the operating room during their DBS lead implantation surgeries. Using patient-specific tractography models prior to surgery, investigators identified the “optimal” target within the SCC for lead placement. Stimulation was then delivered in the operating room over the course of an hour while local field potentials (LFPs)—electrical signals between neurons deep in the brain—were simultaneously recorded.

A machine learning classification method was subsequently used to discriminate between intracranial LFPs recorded at baseline (stimulation-naïve) and after the first exposure to stimulation inside the operating room. Spectral inputs (theta, 4–8Hz; alpha, 9–12Hz; beta, 13–30Hz) to the model were then evaluated for importance to classifier success and tested as predictors of the antidepressant response. A 45.6% decline in depression scores was observed after one week and this early antidepressant response correlated with a decrease in the SCC LFP beta power, which most contributed to classifier success.

Helen S Mayberg (Credit: Mount Sinai Health System)

“We generally think of depression treatment as taking weeks or months to show stable and meaningful changes in core clinical features of the illness,” said Mayberg. “This study shows reproducible and consistent changes in a brain readout over the first minutes of optimised stimulation in the operating room in individual patients. This provides new mechanistic understanding of the ‘depression switch’ that moves a patient from a state of sustained mental pain and immobility to relief, and the renewed capacity to move and engage.”

“This research provides individuals who have struggled with depression a sense of hope through advancements in existing technology,” said John Ngai, director of the NIH BRAIN Initiative. “We are making immense strides in better understanding debilitating brain and mental health conditions through these discoveries, and look forward to seeing how DBS will continue to improve people’s lives.”

Studies that continue to track these brain state biomarkers during ongoing DBS therapy are currently in progress at the Nash Family Center for Advanced Therapeutics at Mount Sinai West, with Phase II of this five-year NIH BRAIN Initiative grant also currently recruiting new subjects.


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