Jan Medical’s Nautilus BrainPulse detected cerebral vasospasm with clinically meaningful accuracy in UCSF study

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Jan Medical has announced that a clinical study published in Neurocritical Care demonstrated that Nautilus BrainPulse is a highly sensitive skull accelerometry that can detect cerebral vasospasm “with clinically meaningful accuracy”, therefore suggesting, “promise in the ICU environment to detect as well as reject cerebral vasospasm as the cause of neurological deficits in subarachnoid haemorrhage.”

Principal investigator for the Nautilus BrainPulse study was Wade S Smith, director, UCSF Neuroscience ICU, Professor of Neurology, University of California, San Francisco, USA.


“What we need is a safe, noninvasive, user-independent method to detect cerebral vasospasm before it causes brain injury,” says Smith. “The technology needs to be simple, and portable, to be most effective in the Neuro Critical Care setting, by more immediately detecting vasospasm so we can aggressively prevent stroke with cerebral angioplasty and/or vasospressor therapy. Such a technology holds the promise to directly help patients and shorten the length of stay within the Neuro ICU.”


“Our Nautilus BrainPulse system can rapidly provide critical information on a patient presenting with stroke symptoms, and it can also be used as a continuous monitor of changes to the cerebral vasculature. It is this latter ability, continuous monitoring, that provides a unique capability in detecting the onset of vasospasm,” adds Paul Lovoi, chief executive officer of Jan Medical. “This study has confirmed that our portable and continuous brain-sensing system can detect vasospasms quickly and noninvasively.”


The Nautilus BrainPulse is designed to measure the normal brain pulse as well as disruptions of the brain pulse. By digitising the signal patterns from headset-mounted sensors measuring the skull’s motion, and extracting features from them, algorithms have been developed to identify normal and a variety of abnormal brain pulse patterns in recording sessions that take approximately three minutes. The device is portable, entirely non-invasive and provides analysis immediately once the recording session is completed.

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