New study results demonstrate value of Cerox cerebral oxidation monitor


Ornim Medical has announced that new study results demonstrate the feasibility of the Cerox cerebral oxidation monitor for measuring regional cerebral tissue oxygenation in patients with severe traumatic brain injury.

According to a press release, the Cerox monitor employs Ornim Medical’s patented UTLight technology, which utilises weak acoustic beams to identify light emerging from deep tissue layers. UTLight harnesses the ability of near-infrared light to measure regional oxygen saturation in combination with ultrasound that can achieve localisation via the acousto-optic effect. The Cerox monitor is the only US Food and Drug Administration-cleared device enabling continuous, non-invasive measurement of blood flow and oxygen saturation in real time.

“Cerox represents a major advance in the care of patients with traumatic brain injury,” says Daryl R Gress, associate professor of Neurology and Neurosurgery, and director of Neurocritical Care, University of Virginia.  “Measuring both blood flow and oxygen saturation in real time allows neurointensivists and neurosurgeons to act quickly and decisively to optimise haemodynamics, blood pressure and intracranial pressure management strategies in the critical care setting.” 

Eighteen patients with severe traumatic brain injury admitted to the intensive care unit requiring intracranial pressure monitoring and advanced neuromonitoring were included in the study. The authors found a strong correlation (r = 0.60, p <0.001) between the jugular bulb venous saturation from the venous blood gas and the Cerox measure of regional cerebral tissue saturation on the side ipsilateral to the catheter. A multivariate analysis revealed that among the physiological parameters of mean arterial blood pressure, intracranial pressure, brain tissue oxygen tension, and Cerox measurements on the ipsilateral and contralateral sides, only ipsilateral Cerox measurements were significantly correlated to jugular bulb venous saturation (p < 0.001). 

The authors concluded that the correlation between the Cerox measurements and the jugular bulb venous measurements of oxygen saturation indicate that the CerOx may be able to provide an estimation of cerebral oxygenation status in a noninvasive manner, the press release reports.


The study is currently available online in the Journal of Neurosurgery, the official journal of the American Association of Neurological Surgeons.