Continuous cell loss in parahippocampal gyrus could signal later diagnosis of Alzheimer’s


The study found that sufferers of a specific type of cognitive impairment have an increased loss of cells in the parahippocampal gyrus which can be vital in detecting which patients will progress to a diagnosis of Alzheimer’s.

A team of researchers from Birmingham City University, UK, in association with colleagues from Lanzhou University, China, and the Alzheimer’s Disease Neuroimaging Initiative, conducted a brain scan analysis over two years, of patients suffering from amnestic mild cognitive impairment (aMCI)a condition involving the diminishing of cognitive abilities, from which 80% of patients progress to a diagnosis of Alzheimer’s.

Scans showed that the loss of grey matter in the left hemisphere of the brain was particularly widespread and degenerative for those patients at high risk of developing Alzheimer’s, compared with those with no active neurological disorders. This region of the brain has been associated with language, decision making, expressing personality, executing movement, planning complex cognitive behaviour and moderating social behaviour. 

One of the researchers involved in the study, Mike Jackson, Birmingham City University, said: “Continuous loss of cells within the regions of the brain highlighted in this study should act as alarm bells for doctors, as they may indicate that the patient is on course to developing Alzheimer’s.”

The parahippocampal gyrus was highlighted as an area that should be looked at carefully when examining brain scans to detect early signs of the disease.